5/15/2023 0 Comments Dorixina relax![]() The Cyclobenzaprine component may enhance the depressant effects of alcohol, barbiturates or other CNS depressants.Ĭaution should be used when administering to patients with a history of digestive diseases like gastroduodenal peptic ulcer or gastritis and in patients treated with anticoagulants.Īlthough no case with the administration of Lysine Clonixinate has been reported, it is known that NSAIDs inhibit the synthesis of prostaglandins which have a supportive role in the maintenance of renal perfusion. In cases of allergic skin and/or mucosal reactions or symptoms of peptic ulcer or gastrointestinal hemorrhage, discontinue treatment with Dorixina Relax. Recent acute myocardial infarction, heart failure, arrhythmia, heart block or conduction disturbances. In patients with a history of bronchospasms, nasal polyps, angioedema or urticaria caused by the administration of acetylsalicylic acid (aspirin) or other NSAIDs.ĭue to the Cyclobenzaprine component it is contraindicated during coadministration of monoamine oxidase inhibitors (IMAO) or within 2 weeks after their discontinuation. Children and adolescents under 15 years of age. Active peptic ulcer or gastroduodenal hemorrhage. Known hypersensitivity to Lysine clonixinate or Cyclobenzaprine. It is eliminated quite slowly with an effective half-life oscillating between 1 and 3 days.ĭorixina Relax is indicated for the treatment of musculoskeletal pain, specially when associated with muscle spasms. It is primarily metabolized in the liver and excreted predominantly via kidney. Its concentration in milk is of about 7-10% of the plasma concentration.Ĭyclobenzaprine is easily absorbed and circulates highly bound to plasma proteins. It is excreted in the form of metabolites, principally in the urine (60%). The plasma half-life of lysine cloxinate in humans is of about 1.75☐.10 hrs (mean ± SD). Its bioavailability is of about 56%, with some individual variability. Lysine clonixinate is rapidly absorbed reaching its peak plasma level about 40-60 minutes following administration. Cyclobenzaprine relieves muscle spasm and reduces tonic somatic motor activity, influencing both gamma and alpha motor systems at central nervous level. The cyclobenzaprine component relieves skeletal muscle spasm of local origin without interfering with muscle function. It was recently shown that it acts principally on the enzyme that catalyzes the production of prostaglandins responsible for inflammation (cyclooxygenase-2 or COX-2) with less activity on the kidneys (cyclooxygenase-1 or COX-1), where these substances exert a protecting role. It exerts its effect by inhibiting prostaglandin synthesis. Further informationĪlways consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Each tablet contains : Lysine clonixinate : 125 mg, Cyclobenzaprine HCl: 5 mg.Įxipients: corn starch microcrystalline cellulose magnesium stearate hydroxypropyl methylcellulose patent blue V aluminium lake titanium dioxide triacetine.ĭorixina Relax due to its lysine cloxinate component is a NSAI drug, with mainly analgesic action. Consult with your healthcare professional before taking any medication. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. ![]() ![]() It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. This means it is still under development and may contain inaccuracies. ![]() Important Notice: The international database is in BETA release. Ingredient matches for Dorixina Relax ClonixinĬlonixin lysine (a derivative of Clonixin) is reported as an ingredient of Dorixina Relax in the following countries:Ĭyclobenzaprine is reported as an ingredient of Dorixina Relax in the following countries:Ĭyclobenzaprine hydrochloride (a derivative of Cyclobenzaprine) is reported as an ingredient of Dorixina Relax in the following countries: Dorixina Relax may be available in the countries listed below.
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